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These findings support the relevance of MGBA mechanisms in BD pathophysiology, implicating both immune and metabolic pathways as shown in Table 8, and are conceptually illustrated through the microbiotaimmunemetabolicbrain axis model (Figure 6

Dysbiosis is a hallmark of DFUs

Given the importance of glutamine metabolism to immune cells, including activated lymphocytes, it is crucial to determine whether blockade of glutamine metabolism in tumor cells hampers anticancer immune responses

After four weeks of twice-daily dosing, you have accumulated roughly 4 to 5 hours of room temperature exposure, which is still well within limits