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Once in the nucleus, Nrf2 binds to antioxidant response elements (AREs) and induces the expression of over 500 cytoprotective genes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx) 9,10,11 , thereby enhancing the cells resilience against more significant stressors

It is a very safe and effective way to treat pigmentation caused by sun damage

Beyond its reproductive toxicity, it significantly impacts human health by disturbing intracellular calcium homeostasis, generating oxidative stress, and interfering with critical cell signaling pathways, ultimately leading to cellular dysfunction (49)

The number of macrophages is positively correlated with NAFL/NASH disease severity, and more macrophages are found even at the early stages of human NASH