glutathione pathway oxidative stress General of metabolism.O 2 ׂ ‾superoxide Glutathione in the Brain |

The consequences of this condition can be devastating and, in some cases, fatal

doi: 10.1016/j.clinthera.2024.01.011 49 CerqueiraF.MedeirosR.LopesI.CamposC.FerrazM

Another study in 2013 indicated that oral administration of the total flavonoids (TFs) from Rosa laevigata Michx fruit decreased blood lipid and glucose levels and ameliorated hepatic fat accumulation through suppressing fatty acid synthesis, promoting fatty acid b-oxidation together with resisting oxidant stress and protecting mitochondria, indicating that TFs provides novel therapeutic potential against HFD-induced NAFLD (Zhang et al., 2013)

In plants, GSH has been shown to be involved in maintaining the redox homeostasis and mediating signals from the ever-changing environment to intracellular target proteins 70