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[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis

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By preserving NAD+ and SAM in both fat and muscle tissue, NNMT inhibition may theoretically address the metabolic dysfunction underlying both excessive fat storage and impaired muscle maintenance