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When left unchecked, free radicals can cause oxidative damage to our cells, DNA, proteins, and lipids

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Another circadian clock protein PER2 inhibits the expression of PAI-1 in a CLOCK/BMAL1-dependent manner as an important factor in the development of these metabolic diseases after the circadian clock system is dysregulated (Oishi et al., 2009)

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doi:10.1038/nature03000 Sosne G, Kleinman HK, Springs C, Gross RH, Sung J, Kang S

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