First-line interventions include: Dietary modification : Adopting a balanced, calorie-controlled diet rich in vegetables, fruits, whole grains, and lean proteins whilst limiting processed foods, saturated fats, and added sugars Regular physical activity : Aiming for at least 150 minutes of moderate-intensity exercise weekly, which improves insulin sensitivity independent of weight loss Alcohol reduction : Even in NAFLD (non-alcohol-related), minimising alcohol consumption supports liver health Management of comorbidities : Optimising control of diabetes, hypertension, and dyslipidaemia through appropriate medications For patients with type 2 diabetes and NAFLD, medications such as pioglitazone (a thiazolidinedione) have shown benefits for liver health in addition to glycaemic control, though this is an off-label use in the UK and carries risks including fluid retention, weight gain and potential heart failure exacerbation
They offer a combined effect that can produce more noticeable results than taking either one alone
Morning dosing also pairs neatly with Vitamin C, since many people already have a Vitamin C-rich breakfast (citrus, amla, guava) or supplement alongside it, supporting the antioxidant recycling covered later in this guide
Intestinal monoacylglycerol metabolism: developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase
