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Appetite regulation Some peptides mimic hormones that signal fullness to the brain

Additional reductions are observed in inflammatory mediators including monocyte chemoattractant protein-1 (MCP-1), inducible nitric oxide (NO) synthase (iNOS), and NO production [66, 109, 110]

Their comparison illustrates the two dominant strategies in modern obesity pharmacotherapy: combination therapy with proven agents versus novel single-molecule multi-agonism