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Although there are a variety of systemic manifestations, the characteristic feature of RA is persistent inflammatory synovitis, usually involving peripheral joints in a symmetric distribution

381 Both SIRT2-catalyzed deacetylation and SIRT5-mediated desuccinylation of PKM2 reduce the activity of PKM2, preventing the carbon entry into the TCA cycle

The intrinsic activity of thyroxine is critical for survival and growth and regulates gene expression in neonatal liver

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