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The N-terminal periplasmic domains also interact with the components of the cytoplasmic membrane-embedded platform of the secretion machinery, to promote channel opening, cargo docking, and subsequent release 26,27

*Correspondence: Yongyin Li, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Viral Immunology, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers