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Phase 2 clinical trial data published in the New England Journal of Medicine (Jastreboff et al., 2023) demonstrated mean body weight reductions of up to approximately 24% over 48 weeks in adults with obesity a notable finding, though long-term durability data and head-to-head comparisons with other treatments are not yet available

At Eternal MedSpa, B12 injections are offered as a convenient wellness-support option for appropriate guests

Beyond commercial feasibility, manufacturing-derived impurities can independently provoke adverse immune responses

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007