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Drugs such as nitroglycerin have been used to relieve angina, as the slow release of NO upon degradation of nitroglycerin causes increased cGMP, resulting in reduced myocardial wall tension, dilation of epicardial coronary vessels, and increased blood flow in collateral vessels

These methods are not evaluated in the review itself, but they represent a growing interest in how glutathione can be supported beyond lifestyle and precursors

Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology

Ramachandra, C