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In vitro and animal-model studies have examined its interaction with angiogenic, nitric-oxide, and growth-factor signalling pathways relevant to soft-tissue research

characterization of its heterogeneity, impurities, and degradation

Psoriasis disease and medical history characteristics included psoriasis disease duration, history of psoriasis in a difficult-to-treat area (scalp, genitals, nails, palms and soles, or inverse/intertriginous areas), history of non-plaque psoriasis (guttate, erythrodermic, or pustular), and the number of previous topical therapies used (corticosteroids, tacrolimus, pimecrolimus, calcipotriene/calcitriol, vitamin D 3 analogue/steroid combination, tar, anthralin, tazarotene, roflumilast, or tapinarof)

Free of strong acids or disruptive actives