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As a small molecule that mimics and potentiates HGF activity while maintaining oral bioavailability and blood-brain barrier penetration, Dihexa offers practical advantages over gene therapy or protein-based approaches for clinical translation

Although it is apparent that both A plaques and tau tangles are present in AD brains, how these two hallmarks interact and contribute to AD pathogenesis remains unclear

Similarly, patients with active malignancy warrant careful consideration given theoretical concerns about angiogenic effects potentially affecting tumor growth, though preclinical evidence suggests context-dependent effects that may inhibit rather than promote tumor angiogenesis