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Description

This MMP-1 inhibition occurs through interference with AP-1 transcription factor binding to the MMP-1 promoter region, reducing collagen degradation rates in dermal matrices

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One is a tetrahedral geometry with three nitrogen atoms and one oxygen atom from three histidine ligands, imitating the active site of CA, and the other is a distorted trigonal bipyramidal geometry also coordinated by the histidine ligands

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