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As a growth hormonederived peptide fragment that operates independently of classical GH receptor pathways, AOD 9604 enables targeted study of metabolic signaling mechanisms without engagement of IGF-1mediated endocrine effects

At the same time, LOS sialylation, regulated by the availability of exogenous sialic acid, the regulation of genes for endogenous sialic acid production, and the expression of Lst sialyltransferase, enhance internalization in immune cells expressing Siglec-5 and sialoadhesin (Jones et al., 2003