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Developments in endoscopic therapy have resulted in a major shift in the treatment of patients with BE who have dysplasia or early EAC, from surgical resection to endoscopic resection and ablation

In addition, other therapeutic arsenals, including DNA-alkylating agents, natural products, antimetabolites, hormone agonists/antagonists, and specific inhibitors, such as kinase inhibitors, monoclonal antibodies, or small organic molecules, are available and are used for cancer therapy (6,7)