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Allosteric Transcriptional Regulation via Changes in the Overall Topology of the Core Promoter

These Cu I binding properties are potentially consistent with a role in Cu storage under Cu-replete or Cu-toxic conditions, 898 or as part of an anticipatory Cu-toxicity response, when cells are chronically metal-starved, and thus particularly vulnerable to mismetalation mediated by even modest Cu toxicity (see Section 5.3.2)