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the one or more hepatocyte growth factor mimics has or have a general structural formula R] is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s-benzyl cysteine

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FOXO4-DRI successfully removed senescent chondrocytes, and the results confirmed that removal of senescent cells significantly increased cartilage formation potential and reduced degenerative enzyme production