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A review of GH secretagogue pharmacology notes that preserving this pulsatile pattern keeps natural negative feedback intact [2]

Treatment of such events usually involves discontinuation of DPA (and the use of another anti-copper drug), but in more severe cases, temporary treatment with steroids is suggested to reduce the autoimmune response and clinical symptoms associated with a DPA-related adverse event [160]

[Updated 2023 May 8]

Finally, the review will discuss therapeutic strategies targeting GPX4 and ferroptosis, including pharmacological and gene therapies, and analyze the main challenges in this field and potential future research directions