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Regul Pept 156(13):8389 Barisic I, Balenovic D, Klicek R et al (2013) Mortal hyperkalemia disturbances in rats are NO-system related

The additive benefit is most pronounced in striae albae, where the microchannel access created by needling dramatically improves delivery of active agents to the dermal level that topical application cannot reach

This only makes the situation worse, as the high GH levels only further increase the already elevated insulin-like growth factor-1 (IGF-1) concentrations

Topical Administration (Most Common) The most widely used approach is topical application via DMSO (dimethyl sulfoxide): Dissolve 3-5mg Dihexa in a few drops of DMSO Apply to forearm skin (DMSO acts as a carrier to drive the peptide through the skin) DMSO concentration: ~20-30% in the solution Pros: Effective absorption, avoids injection Cons: DMSO has a strong garlic-like odor that can transfer to breath/skin Starting Dose Begin at 1-3mg topically to assess response Work up to 3-5mg if tolerating well Cycling Protocol Dihexa appears to have lasting effects that persist after stopping likely due to synaptogenesis (new connections don't disappear when you stop)