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Verdin, E

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The receptors for glutamate are broadly categorized into two classes, i.e., ionotropic glutamate and metabotropic receptors ( 2+ influx), kainate, and AMPA (Na + Influx) receptors, while the latter one includes G protein-coupled receptors that activate the intracellular cascade ( + and Na + ions, respectively, which leads to the imbalance of excitatory and inhibitory pathways and therefore, these two receptors represent key clinical research targets (Hanada, 2020)