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416 Experimental models of depression also demonstrate uncoupling of astrocytic syncytia, whereas pharmacological inhibition of gap junctions by intracerebral infusion of carbenoxolone induced anhedonia and anxiety-like behaviour

This finding is in line with the improved tolerance achieved by engineering GSH biosynthesis even in the obligate anaerobe Clostridium acetobutylicum against aeration and butanol challenge [67]

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However, as with any peptide protocol, medical supervision and regular monitoring optimize both safety and results