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In calves experimentally coinfected with BRSV and Pasteurella multocida , feeding with Saccharomyces cerevisiae fermentation products (SCFP) attenuated pulmonary inflammatory responses and enhanced pulmonary plasminogen expression as well as the expression of genes involved in glutathione metabolism, indicating that gut-derived interventions can reshape systemic and pulmonary immunity 177

Altered intestinal permeability (leaky gut) allows the passage of food antigens, toxins, bacteria, and microbial products, promoting inflammation and dysregulated immune responses, triggering autoimmunity through various mechanisms [188]

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