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Ethics declarations Ethics approval and consent to participate The study protocol involving human tissues adhered to the Declaration of Helsinki and was approved by the review board of Renmin Hospital of Wuhan University (WDRY2021-KS047)

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Possible ethical considerations are heightened by the anticipated FDA approval of these tests for use in primary care settings, where health care professionals may not be as familiar with the critical distinction between detection and diagnosis as specialists are, nor as equipped to accurately convey this to patients as they weigh the benefits and risks of such tests

[79] used electronic spraying method to prepare insulin-loaded alginate microparticles (Figure 5C)