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The clinical literature confirms that women have higher baseline GH secretion than men during their reproductive years, partly because estrogen stimulates GH release from the pituitary

A study involving the TAM-resistant cell lines named MCF-7/LCC2 and MCF-7/LCC9 reported that the combined use of curcumin and TAM resulted in synergistic growth inhibition, an increase in the sensitivity of MCF-7/LCC2 and MCF-7/LCC9 cells to TAM, and a reduction in IC 50 of TAM (Jiang et al., 2013)

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