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HG-induced iron overload generates hydroxyl radicals, causing mitochondrial membrane potential (MMP) depolarization, mtDNA damage, and dysfunction (139142)

75 After structural modification, ursolic acid shows higher efficacy and diverse targets and can inhibit the processes leading to cancer pathology

J Amino Acid 10(1125):126 Lv H, Zhen C, Liu J, Yang P, Hu L, Shang P (2019) Unraveling the potential role of glutathione in multiple forms of cell death in cancer therapy

This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate sodium (DSS)-induced murine model of UC, with particular emphasis on elucidating its regulatory effects on the NAD-dependent deacetylase sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway