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Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination
For people with genetic variants that cause more of an impact on CYP1B1 upregulation combined with an inability to eliminate the estrogen metabolites fast enough (due to phase II genes, diet, and lifestyle) then cigarette smoking is going to significantly increase the bad estrogen metabolites
It also supports nerve regeneration and reduces oxidative stress two mechanisms thought to underlie its benefits for diabetic neuropathy.48 Randomized trials have shown that taking 1,0002,000mg of ALCAR daily may help reduce pain, improve vibration perception, and enhance nerve conduction in people with diabetic neuropathy especially when treatment begins early.49 Vibration perception refers to the ability to sense low-frequency vibrations, such as those from tuning forks a key part of nerve function often tested in clinical exams to assess sensory loss in the feet and legs
Schroder, S., Hoch, W., Becker, C
