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And rightly so

Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study

Cardiovasc Res 113(4):399410

Moreover, the GSH concentration and its ratio with GSSG concentration were strongly, and positively, correlated with hepatic CBS activity, indicating that Sal A-induced GSH increase and subsequent alteration in GSH/GSSG ratio was associated with its activatory effect on CBS activity