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51 DefrancescoM.MarksteinerJ.KemmlerG.Dal-BiancoP.RansmayrG.BenkeT.et al (2020)

Those with chronic migraines had increased daytime sleepiness and dysthymia (a mild form of depression) compared to those with episodic migraines

Commonly, there are pulmonary congestion, heart dilatation and insufficient heart contrast filling (venography in the superior sagittal sinus, right external jugular vein), poor inferior caval vein compliance, huge congestion within prominent hepatic veins without parenchymal liver phase (venography through inferior caval vein)

Reading every flat week as a cue to escalate is how people climb past the dose they actually needed, importing side effects without adding benefit