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Introduction Type 2 diabetes (T2D) is a chronic disease affecting more than half a billion people worldwide its prevalence has almost doubled since 1990 and it is estimated that by 2050 over 1.3 billion people will live with T2D, posing a major public health challenge with substantial impact on healthcare systems, patients and their families [1]

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A main action is reducing the disulfide bonds in cysteine units in proteins thus reducing the protein while GSH itself is oxidized to GSSH

N3 bears a lactam ring, an aliphatic isobutyl group, an isopropyl group, a methyl group and an isoxazole as the side chain for the P1P5 sites, respectively