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HGF/c-Met pathway is one of the most dysregulated pathways in human malignancies, which include, but are not limited to: bladder, breast, cervical, colorectal, endometrial, esophageal, gastric, head and neck, kidney, liver, lung, nasopharyngeal, ovarian, pancreatic, prostate, and thyroid cancers ( Activation of Met in cancer occurs most often through ligand autocrine or paracrine activation

In studies the application was not circumferential, and in some instances, exceeded well into the submucosal tissue, and in others, not deep enough into the epithelium

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