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BPC-157 was moved out of the more restrictive Category 2 classification so it could be formally reviewed, but a reclassification is procedural, not an approval

A preclinical safety evaluation published in ScienceDirect confirmed that BPC-157 caused mild local irritation but demonstrated good overall tolerance across mice, rats, rabbits, and dogs

Topical Vitamin B12--a New Therapeutic Approach in Atopic Dermatitis-Evaluation of Efficacy and Tolerability in a Randomized Placebo-Controlled Multicentre Clinical Trial

In other embodiments, the otic gel formulations are applied via microcathethers implanted into the patient, and in yet further embodiments the formulations are administered via a pump device onto or near the round window membrane