As the extent of their methylation was much lower in the brain and in lower passage astrocytes, the authors concluded that their high methylation may just be an in vitro artifact of the prolonged passaging of cells (Meissner et al., 2008), a phenomenon that was previously observed (Shen et al., 2006
Statements Data availability statement The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation
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Notably, HO-1 mitochondrial translocation has also been detected in several cell types in response to hypoxia, leading to mitochondrial ROS accumulation and dysfunction 56