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Front Neurol 9:393 Funding This work was supported by National Natural Science Foundation of China (82411540241, 82471974, 82503497), Joint Funds for the innovation of science and Technology, Fujian province (2024Y9686)

Importantly, evidence from tissue-specific transgenic or knockout animal models of PGC-1s have supported this notion

This underscores that GSTM1 and GSTT1 genotypes are key determinants for stratifying individuals who would derive maximum benefit from SFN-based chemoprevention for colorectal cancer, with age and smoking history providing critical contextual refinement