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*Safety of FIRDAPSE was evaluated in pediatric patients in an expanded access program, where 21 pediatric patients received FIRDAPSE for at least 1 year

Angiogenesis (Blood Vessel Formation) One of the more interesting mechanisms is its ability to promote angiogenesisthe formation of new blood vessels

(I) The relevant mechanisms involved in each step of the intracellular GSH exhaustion process need to be further explored, and the biological effect of cancer cells after GSH depletion remains to be elucidated

These agents are particularly useful as add-on therapies but may also suffer from incomplete CNS penetration and systemic side effects such as hypertension and insomnia due to their off-target activity