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Of note, the exaggerated levels of pro-inflammatory mediators and the suppressed AKT level are considered the key contributors in disrupting BDNF signaling, which lead to consequent enhancement in neuronal apoptosis and impairment in memory functions (Rossi et al

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Redefine 1 trial showed CagriSema led to significant weight loss, with 91.9% achieving 5% body weight reduction, compared to 31.5% in the placebo group