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Lifestyle changes for MCAS: Low-histamine Diet: Allergy elimination diets and low-histamine diets have been shown in studies to be helpful to some people with chronic itching (one symptom of MCAS)

The reactive arm identifies proteins that escape productive folding or become damaged over time and routes them into clearance or repair pathways, primarily the ubiquitinproteasome system and lysosomal autophagy (Fig