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19 November 2025

The 2022 American College of Cardiology Expert Consensus Decision Pathway and the 2019 ESC/EAS dyslipidemia guideline support intensifying lipid-lowering therapy in high-risk patients using statins, ezetimibe, PCSK9 inhibitors, bempedoic acid, inclisiran, and other agents depending on risk category and response (Lloyd-Jones et al., 2022

Multiple sessions are often required for optimal results, and downtime is generally minimal

To analyze this, we conducted rescue experiments by re-expressing wildtype TBC1D9B-HA or a GAP activity-defective point mutant with mutations in the arginine (R) and glutamine (Q) fingers 38,40 (i.e., R559A/Y592A/Q594A (TBC1D9B RYQ/AAA )) (see also Fig