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For example, DNA strand breaks and reversible cross-links with DNA or histone proteins of nucleosome core particles from AP sites affect transcription and replication in cells, further inducing gene mutations, which may cause apoptosis or cell carcinogenesis [19, 20]

Overall, methotrexate remains an indispensable option in psoriasis management, particularly for those seeking a balance between efficacy and cost (Murage et al