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Description

The production of ROS can be induced by exposure to various factors, such as heavy metals, tobacco, smoke, drugs, exogenous substances, pollutants, and radiation [59]

For physicians, the delivery choice is a trade-off between several factors: bioavailability, dosing reliability, convenience, cost, and clinical fit

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In some embodiments, a high viscosity otic formulation or device described herein provides an apparent viscosity of from about 100,000 cP to about 1,000,000 cP