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114 Gastrodin (GAS), derived from Gastrodia elata , along with Irisin, a soluble peptide upregulated by the PGC-1 signaling pathway, and Mitochonic acid-5, a mitochondrial homing drug, all activate the SIRT3/Parkin pathway, thus enhancing mitochondrial membrane potential and promoting mitophagy

PMC 6517119

It is likely that the most well-known function of NADPH oxidase-derived superoxide is the inactivation of NO in the reaction that forms peroxynitrite, which leads to impaired endothelium dependent vasodilation and the uncoupling of endothelial NO synthase (eNOS) to produce additional superoxide

Oxid Stress Toxicity Reprod Biol Medicine: A Compr Update Male Infertility-Volume One