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McCarter et al

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It includes a review of existing data, an evaluation of potential therapeutic strategies, and the development of new approaches for their clinical application

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These senescent cells release harmful pro-inflammatory signals, known as the senescence-associated secretory phenotype (SASP), that damage surrounding tissues and disrupt overall organ function

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The key is to treat optimization like an experiment measure, adjust, and let your physiology guide the protocol changes (if any)

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