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Mechanistically, ER transcriptionally upregulated the expression of SLC7A11 and SLC3A2, two subunits of the system x c , which is one key inhibitory regulator of ferroptosis

Additionally, treatment with 10 nM E2, for 7 days, stimulated differentiation to the neuronal lineage, and inhibited differentiation to astrocytes (Zhang et al., 2019)

Holocarboxylase Synthetase Deficiency Deficiency in holocarboxylase synthetase is an autosomal recessive disorder that results in multiple carboxylase deficiency