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The B2M contributes to immune-related aspects of ageing 73 , while SOD1 mitigates oxidative damage through its function as a frontline antioxidant enzyme 75

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The distance between the two IPT2 domains of c-METs in this structure is ~20 , hinting that the two membrane-proximal IPT4 domains of c-METs are likely to be positioned in proximity in this specific dimeric conformation that allows the intracellular KDs to undergo trans -autophosphorylation