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Exposure of healthy organs to medication is unnecessary and most often will lead to side or toxic effects which are especially an issue for medication with a narrow therapeutic index

Neuronal inflammation was also attenuated by suppression of the HMGB1 (high mobility group box-1)/TLR4 (toll-like receptors)/NLRP3 (nod-like receptor protein) inflammasome [52]

Yeast biotechnology: diversity and applications 2009:259 80 Forman HJ, Zhang H, Rinna A (2009) Glutathione: overview of its protective roles, measurement, and biosynthesis