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2) Develop standardized, clinically applicable biomarkers: Establish a multi-tiered biomarker panel combining biofluid-based markers (e.g., plasma oxPCs and urinary ferroptosis-related miRNAs) and tissue-based spatial signatures (e.g., ACSL4/GPX4 expression ratio in PT cells)

The results showed that the overexpression of ATP6AP1L gene with pcDNA3.1-GST DAF -ATP6AP1L and pcDNA3.1-GST CEAM7 -ATP6AP1L could significantly inhibit the proliferation of K-562 cells compared with the control cells transfected with empty vectors, pcDNA3.1-GST DAF, and pcDNA3.1-GST CEAM7 , respectively

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