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The breadth of systemic activity reflects the peptide's interaction with foundational signaling pathways (NO, VEGF, growth hormone receptor) that operate across nearly all tissue systems

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NAADP induces the lysosomal Ca 2+ efflux and calcineurin-mediated TFEB activation, which enhances the expression of pro-inflammatory cytokines including IL-1, IL-1 and IL-6

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