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A specific variant of the MOTS-C gene also shows up in Japanese centenarians at higher rates than in the general population

Because half of the isomers present as a mixture in synthetic -tocopherol are not usable by the body, synthetic -tocopherol is less bioavailable than natural -tocopherol (see Figure 1 )

One study demonstrated that gluconeogenic intermediates, such as pyruvate, malate, and phosphoenolpyruvate (PEP), are neuroprotective against MPP + toxicity

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