Goncalves-Ribeiro S, Diaz-Maroto NG, Berdiel-Acer M, Soriano A, Guardiola J, Martinez-Villacampa M et al
Injectable anti-ageing protocol: 12 mg daily or 5 days on / 2 off , cycle 30 days on / 14 days off , minimum 23 cycles for substantial change Topical anti-ageing protocol: 2 %3 % serum, twice daily, minimum 12 weeks continuous use, paired with daily SPF 50 sunscreen Combination protocol: low-dose injectable ( 1 mg 3/week) + topical 2 % serum daily - typically the most powerful approach for patients 40+ See our related pieces on anti-ageing treatments in Mumbai and how to look younger without looking fake
[DOI] [PMC free article] [PubMed] [Google Scholar] Sahay A., Scobie K.N., Hill A.S., O'Carroll C.M., Kheirbek M.A., Burghardt N.S., Fenton A.A., Dranovsky A., Hen R
But they come with significant drawbacks: high cost, injection site reactions, increased infection risk due to immune suppression, and the development of anti-drug antibodies over time that can reduce efficacy