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Comparators included a health promotion intervention [34], a brief consultation along with waitlist control [35], very brief advice [27], health education [3032], hypnotherapy [29], and minimal interventions [33]

The review underscores the role of cigarette smoke, particularly polycyclic aromatic hydrocarbons (PAHs), in modulating the metabolic pathways of antidiabetic drugs, primarily through the induction of cytochrome P450 (CYP450) enzymes and uridine diphosphate (UDP)-glucuronosyltransferases (UGTs), thus impacting drug pharmacokinetics and therapeutic outcomes